Metabolism: Modafinil undergoes hepatic metabolism via a number of pathways, such as CYP3A4. 80% of your dose is recovered inside the urine in the shape of metabolites.anastrozole will increase the degree or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.Istradefylline forty mg

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